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Anti-Mob1A MOB1B Antibody

Boster Bio Anti-Mob1A MOB1B Antibody catalog # A09405-2. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse.

Product Specifications

Synonyms

MOB kinase activator 1B; Mob1 homolog 1A; Mob1A; Mob1B; Mps one binder kinase activator-like 1A; MOB1B; MOB4A, MOBKL1A;

Gene Name

MOB1B

UniProt

Q7L9L4

Host

Rabbit

Reactivity

Human, Mouse, Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human MOL1A. AA range:101-150

Clonality

Polyclonal

Tissue Specificity

Adrenal gland, bone marrow, brain, lung, placenta, prostate, salivary gland, skeletal muscle, testis, thymus, thyroid gland, uterus, colon with mucosa, fetal brain and fetal liver.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Activator of LATS1/2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. Stimulates the kinase activity of STK38L.

Molecular Weight

25091 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A09405-2

Product MSDS

https://www.bosterbio.com/msds?sku=A09405-2

Fragment

IgG

Other Gene Names

MOB kinase activator 1B

Subcellular Location

Cytoplasm

Protein Name

MOB kinase activator 1B

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