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Anti-IPMK Antibody

Boster Bio Anti-IPMK Antibody catalog # A06955-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Product Specifications

Synonyms

Inositol polyphosphate multikinase;2.7.1.151; Inositol 1,3,4,6-tetrakisphosphate 5-kinase; IPMK; IMPK;

Gene Name

IPMK

UniProt

Q8NFU5

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human IPMK. AA range:311-360

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with the highest expression in skeletal muscle, liver, placenta, lung, peripheral blood leukocytes, kidney, spleen and colon.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Inositol phosphate kinase with a broad substrate specificity. Has a preference for inositol 1,4,5-trisphosphate (Ins (1,4,5) P3) and inositol 1,3,4,6-tetrakisphosphate (Ins (1,3,4,6) P4) (PubMed:12027805, PubMed:12223481) . Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:29883610) .

Molecular Weight

47222 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Inositol polyphosphate multikinase

Subcellular Location

Nucleus

Protein Name

Inositol polyphosphate multikinase

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