Anti-IL-17RC Antibody

Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; Interleukin-17 receptor homolog; IL17Rhom; Interleukin-17 receptor-like protein; IL-17RL; ZcytoR14; IL17RC; UNQ6118/PRO20040/PRO38901;

Expressed in prostate, skeletal muscle, kidney and placenta (at protein level) (PubMed:11706037) . Expressed in brain, cartilage, colon, heart, intestine, kidney, liver, lung, muscle, placenta, and prostate (PubMed:11706037) . Also detected in thyroid, trachea and adrenal gland (PubMed:17911633) . Low expression in thymus and leukocytes (PubMed:11706037) .

Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495) . Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971) . Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633) . Activation of IL17RC leads to induction of expression of inflammatory chemokines and cytokines such as CXCL1 (PubMed:16785495) .