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Anti-GRK 4 Antibody

Boster Bio Anti-GRK 4 Antibody catalog # A04238-1. Tested in ELISA, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

G protein-coupled receptor kinase 4;2.7.11.16; G protein-coupled receptor kinase GRK4; ITI1; GRK4; GPRK2L, GPRK4;

Gene Name

GRK4

UniProt

P32298

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from GRK 4 . at AA range: 10-90

Clonality

Polyclonal

Tissue Specificity

Isoform 1, isoform 2, isoform 3, and isoform 4 are expressed in testis. Isoform 4 is expressed in myometrium.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Specifically phosphorylates the activated forms of G protein-coupled receptors. GRK4-alpha can phosphorylate rhodopsin and its activity is inhibited by calmodulin; the other three isoforms do not phosphorylate rhodopsin and do not interact with calmodulin. GRK4-alpha and GRK4-gamma phosphorylate DRD3. Phosphorylates ADRB2.

Molecular Weight

66583 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

G protein-coupled receptor kinase 4

Subcellular Location

Cytoplasm. Cytoplasm, cell cortex. Both at the cell surface and dispersed in the cytoplasm under basal conditions. Receptor stimulation results in the internalization of GRK4 to the perinuclear area, where colocalization with DRD3 is observed strongly at 5 and 15 minutes. DRD3 and GRK4 colocalize in lipid rafts of renal proximal tubule cells.

Protein Name

G protein-coupled receptor kinase 4

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