Anti-GPR37L1 Antibody

G-protein coupled receptor (PubMed:27072655) . Has been shown to bind the neuroprotective and glioprotective factor prosaposin (PSAP), leading to endocytosis followed by an ERK phosphorylation cascade (PubMed:23690594) . However, other studies have shown that prosaposin does not increase activity (PubMed:27072655, PubMed:28688853) . It has been suggested that GPR37L1 is a constitutively active receptor which signals through the guanine nucleotide-binding protein G (s) subunit alpha (PubMed:27072655) . Participates in the regulation of postnatal cerebellar development by modulating the Shh pathway (By similarity) . Regulates baseline blood pressure in females and protects against cardiovascular stress in males (By similarity) . Mediates inhibition of astrocyte glutamate transporters and reduction in neuronal N-methyl-D-aspartate receptor activity (By similarity) .