Anti-N-arachidonyl glycine receptor GPR18 Antibody

Expressed in midpiece of spermatozoon (at protein level) (PubMed:27572937) . Most abundant in testis and spleen (PubMed:16844083) . Highly expressed in CD4 and CD8-positive T-cells as well as CD19-positive B-cells (PubMed:16844083) .

Receptor for endocannabinoid N-arachidonyl glycine (NAGly) (PubMed:16844083, PubMed:24762058, PubMed:27572937) . However, conflicting results about the role of NAGly as an agonist are reported (PubMed:27018161) . Can also be activated by plant- derived and synthetic cannabinoid agonists (PubMed:24762058) . The activity of this receptor is mediated by G proteins which inhibit adenylyl cyclase (PubMed:16844083) . May contribute to regulation of the immune system. Is required for normal homeostasis of CD8+ subsets of intraepithelial lymphocytes (IELs) (CD8alphaalpha and CD8alphabeta IELs) in small intstine by supporting preferential migration of CD8alphaalpha T-cells to intraepithelial compartment over lamina propria compartment, and by mediating their reconstitution into small intestine after bone marrow transplant (By similarity) . Plays a role in hypotensive responses, mediating reduction in intraocular and blood pressure (By similarity) . Mediates NAGly-induced process of reorganization of actin filaments and induction of acrosomal exocytosis (PubMed:27572937) .