Anti-GPR124 ADGRA2 Antibody

Expressed in endothelial cells (at protein level) (PubMed:15021905, PubMed:16982628) . Abundantly expressed in heart, placenta, ovary, small intestine, and colon (PubMed:15021905) .

Endothelial receptor which functions together with RECK to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314) . Plays a key role in Wnt7-specific responses, such as endothelial cell sprouting and migration in the forebrain and neural tube, and establishment of the blood-brain barrier (By similarity) . Acts as a Wnt7-specific coactivator of canonical Wnt signaling: required to deliver RECK-bound Wnt7 to frizzled by assembling a higher- order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314) . ADGRA2- tethering function does not rely on its G-protein coupled receptor (GPCR) structure but instead on its combined capacity to interact with RECK extracellularly and recruit the Dishevelled scaffolding protein intracellularly (PubMed:30026314) . Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate (PubMed:16982628) .