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Anti-Fish SH3PXD2A Antibody

Boster Bio Anti-Fish SH3PXD2A Antibody catalog # A05241. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

SH3 and PX domain-containing protein 2A; Adapter protein TKS5; Five SH3 domain-containing protein; SH3 multiple domains protein 1; Tyrosine kinase substrate with five SH3 domains; SH3PXD2A; FISH, KIAA0418, SH3MD1, TKS5;

Gene Name

SH3PXD2A

UniProt

Q5TCZ1

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from the N-terminal region of human Fish.

Clonality

Polyclonal

Tissue Specificity

Found in several cancer cell lines, particularly invasive breast carcinomas and melanomas.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Adapter protein involved in invadopodia and podosome formation, extracellular matrix degradation and invasiveness of some cancer cells. Binds matrix metalloproteinases (ADAMs), NADPH oxidases (NOXs) and phosphoinositides. Acts as an organizer protein that allows NOX1- or NOX3-dependent reactive oxygen species (ROS) generation and ROS localization. In association with ADAM12, mediates the neurotoxic effect of amyloid-beta peptide.

Molecular Weight

125289 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

SH3 and PX domain-containing protein 2A

Subcellular Location

Cytoplasm. Cell projection, podosome. Cytoplasmic in normal cells and localizes to podosomes in SRC-transformed cells.

Protein Name

SH3 and PX domain-containing protein 2A

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