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Anti-EDEM2 Antibody

Boster Bio Anti-EDEM2 Antibody catalog # A08174. Tested in ELISA, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

ER degradation-enhancing alpha-mannosidase-like protein 2; EDEM2; C20orf31, C20orf49; UNQ573/PRO1135;

Gene Name

EDEM2

UniProt

Q9BV94

Host

Rabbit

Reactivity

Human

Immunogen

Synthesized peptide derived from the C-terminal region of human EDEM2.

Clonality

Polyclonal

Tissue Specificity

Expressed ubiquitously in all tissues tested with slightly higher levels detected in small intestine and peripheral blood leukocytes and weakest levels in brain and skeletal muscle.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Involved in the endoplasmic reticulum-associated degradation (ERAD) pathway that targets misfolded glycoproteins for degradation in an N-glycan-dependent manner (PubMed:15537790, PubMed:25092655) . May initiate ERAD by promoting the first mannose trimming step of ERAD substrates, from Man9GlcNAc2 to Man8GlcNAc2 (PubMed:25092655) . Seems to recognize and bind to exposed hydrophobic regions in target proteins (By similarity) .

Molecular Weight

64753 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

ER degradation-enhancing alpha-mannosidase-like protein 2

Subcellular Location

Endoplasmic reticulum lumen

Protein Name

ER degradation-enhancing alpha-mannosidase-like protein 2

Frequently Asked Questions

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