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Anti-CLIC4 Antibody

Boster Bio Anti-CLIC4 Antibody catalog # A03210. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Chloride intracellular channel protein 4; Intracellular chloride ion channel protein p64H1; CLIC4;

Gene Name

CLIC4

UniProt

Q9Y696

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human CLIC4. AA range:1-50

Clonality

Polyclonal

Tissue Specificity

Detected in epithelial cells from colon, esophagus and kidney (at protein level) . Expression is prominent in heart, kidney, placenta and skeletal muscle.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Can insert into membranes and form poorly selective ion channels that may also transport chloride ions. Channel activity depends on the pH. Membrane insertion seems to be redox-regulated and may occur only under oxydizing conditions. Promotes cell- surface expression of HRH3. Has alternate cellular functions like a potential role in angiogenesis or in maintaining apical- basolateral membrane polarity during mitosis and cytokinesis. Could also promote endothelial cell proliferation and regulate endothelial morphogenesis (tubulogenesis) .

Molecular Weight

28772 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Chloride intracellular channel protein 4

Subcellular Location

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasmic vesicle membrane ; Single-pass membrane protein . Nucleus matrix. Cell membrane ; Single-pass membrane protein . Mitochondrion. Cell junction. Colocalized with AKAP9 at the centrosome and midbody. Exists both as soluble cytoplasmic protein and as membrane protein with probably a single transmembrane domain. Present in an intracellular vesicular compartment that likely represent trans-Golgi network vesicles.

Protein Name

Chloride intracellular channel protein 4

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