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Anti-Che-1 AATF Antibody

Boster Bio Anti-Che-1 AATF Antibody catalog # A03945-2. Tested in ELISA, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Protein AATF; Apoptosis-antagonizing transcription factor; Rb-binding protein Che-1; AATF; CHE1, DED; HSPC277;

Gene Name

AATF

UniProt

Q9NY61

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human AATF. AA range:10-59

Clonality

Polyclonal

Tissue Specificity

Ubiquitously expressed. Expressed at high levels in brain, heart, kidney, placenta and thymus.

Applications

ELISA, IHC-P, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

May function as a general inhibitor of the histone deacetylase HDAC1. Binding to the pocket region of RB1 may displace HDAC1 from RB1/E2F complexes, leading to activation of E2F target genes and cell cycle progression. Conversely, displacement of HDAC1 from SP1 bound to the CDKN1A promoter leads to increased expression of this CDK inhibitor and blocks cell cycle progression. Also antagonizes PAWR mediated induction of aberrant amyloid peptide production in Alzheimer disease (presenile and senile dementia), although the molecular basis for this phenomenon has not been described to date.

Molecular Weight

63133 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Protein AATF

Subcellular Location

Nucleus, nucleolus

Protein Name

Protein AATF

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