Anti-Apelin receptor APLNR Antibody

Expressed in heart, brain, kidney, stomach, spleen, thymus, lung, ovary, small intestine and colon, adipose tissues and pancreas (PubMed:8294032, PubMed:25639753) . Expressed in glial cells, astrocytes and neuronal subpopulations (PubMed:8294032) . Expressed in embryonic (ESCs) and induced (iPSCs) pluripotent stem cells (PubMed:25639753) .

Receptor for apelin receptor early endogenous ligand (APELA) and apelin (APLN) hormones coupled to G proteins that inhibit adenylate cyclase activity (PubMed:11090199, PubMed:25639753, PubMed:28137936) . Plays a key role in early development such as gastrulation, blood vessels formation and heart morphogenesis by acting as a receptor for APELA hormone (By similarity) . May promote angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis (By similarity) . Promotes sinus venosus (SV) - derived endothelial cells migration into the developing heart to promote coronary blood vessel development (By similarity) . Plays also a role in various processes in adults such as regulation of blood vessel formation, blood pressure, heart contractility and heart failure (PubMed:25639753, PubMed:28137936) .