Anti-Apoptosis inhibitor 5 API5 Antibody
Boster Bio Anti-Apoptosis inhibitor 5 API5 Antibody catalog # A04637. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Apoptosis inhibitor 5; API-5; Antiapoptosis clone 11 protein; AAC-11; Cell migration-inducing gene 8 protein; Fibroblast growth factor 2-interacting factor; FIF; Protein XAGL; API5; MIG8;
Gene Name
API5
UniProt
Q9BZZ5
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
The antiserum was produced against synthesized peptide derived from human API-5. AA range:421-470
Clonality
Polyclonal
Tissue Specificity
Expressed in all tissues tested, including heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highest levels in heart, pancreas and placenta. Highly expressed in several cancers. Preferentially expressed in squamous cell carcinoma versus adenocarcinoma in non-small cell lung cancer.
Applications
WB, IHC, ELISA
Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Form
Liquid
Function
Antiapoptotic factor that may have a role in protein assembly. Negatively regulates ACIN1. By binding to ACIN1, it suppresses ACIN1 cleavage from CASP3 and ACIN1-mediated DNA fragmentation. Also known to efficiently suppress E2F1-induced apoptosis. Its depletion enhances the cytotoxic action of the chemotherapeutic drugs.
Molecular Weight
59005 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Apoptosis inhibitor 5
Subcellular Location
Nucleus
Protein Name
Apoptosis inhibitor 5
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