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Anti-Phospho-TBC1D4 (T642) Antibody

Boster Bio Anti-Phospho-TBC1D4 (T642) Antibody catalog # A02004T642-1. Tested in IF, ICC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

TBC1 domain family member 4; Akt substrate of 160 kDa; AS160; TBC1D4; AS160, KIAA0603;

Gene Name

TBC1D4

UniProt

O60343

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human AS160 around the phosphorylation site of Thr642. AA range:611-660

Clonality

Polyclonal

Tissue Specificity

Widely expressed. Isoform 2 is the highest overexpressed in most tissues. Isoform 1 is highly expressed in skeletal muscle and heart, but was not detectable in the liver nor in adipose tissue. Isoform 2 is strongly expressed in adrenal and thyroid gland, and also in lung, kidney, colon, brain and adipose tissue. Isoform 2 is moderately expressed in skeletal muscle. Expressed in pancreatic Langerhans islets, including beta cells (at protein level) . Expression is decreased by twofold in pancreatic islets in type 2 diabetes patients compared to control subjects. Up-regulated in T-cells from patients with atopic dermatitis.

Applications

IF, ICC

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake.

Molecular Weight

146563 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

Rabbit IgG

Other Gene Names

TBC1 domain family member 4

Subcellular Location

Cytoplasm

Protein Name

TBC1 domain family member 4

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