2-Methylquinazolin-4-ol
2-Methylquinazolin-4-ol is a potent competitive poly (ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].
Product Specifications
CAS Number
[1769-24-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
PARP
Type
Natural Products
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/2-methylquinazolin-4-ol.html
Purity
99.98
Solubility
DMSO : 50 mg/mL (ultrasonic) |H2O : < 0.1 mg/mL
Smiles
O=C1NC(C)=NC2=C1C=CC=C2
Molecular Formula
C9H8N2O
Molecular Weight
160.18
Precautions
H302, H315, H319, H335
References & Citations
[1]S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly (ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo) . 1991 Jan;44 (1) :111-2.|[2]Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23 (4) :483-92.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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