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Anti-Phospho-VHL (S68) Antibody

Boster Bio Anti-Phospho-VHL (S68) Antibody catalog # A00079S68. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Von Hippel-Lindau disease tumor suppressor; Protein G7; pVHL; VHL;

Gene Name

VHL

UniProt

P40337

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human VHL around the phosphorylation site of Ser68. AA range:34-83

Clonality

Polyclonal

Tissue Specificity

Expressed in the adult and fetal brain and kidney.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia- inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2.

Molecular Weight

24153 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00079S68

Product MSDS

https://www.bosterbio.com/msds?sku=A00079S68

Fragment

IgG

Other Gene Names

Von Hippel-Lindau disease tumor suppressor

Subcellular Location

Isoform 1: Cytoplasm. Membrane; Peripheral membrane protein. Nucleus. Found predominantly in the cytoplasm and with less amounts nuclear or membrane-associated. Colocalizes with ADRB2 at the cell membrane.

Protein Name

Von Hippel-Lindau disease tumor suppressor

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