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Anti-Phospho-MDC1 (S513) Antibody

Boster Bio Anti-Phospho-MDC1 (S513) Antibody catalog # A01252S513. Tested in ELISA, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Mediator of DNA damage checkpoint protein 1; Nuclear factor with BRCT domains 1; MDC1; KIAA0170, NFBD1;

Gene Name

MDC1

UniProt

Q14676

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human MDC1 around the phosphorylation site of Ser513. AA range:479-528

Clonality

Polyclonal

Tissue Specificity

Highly expressed in testis.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Required for checkpoint mediated cell cycle arrest in response to DNA damage within both the S phase and G2/M phases of the cell cycle. May serve as a scaffold for the recruitment of DNA repair and signal transduction proteins to discrete foci of DNA damage marked by 'Ser-139' phosphorylation of histone H2AFX. Also required for downstream events subsequent to the recruitment of these proteins. These include phosphorylation and activation of the ATM, CHEK1 and CHEK2 kinases, and stabilization of TP53 and apoptosis. ATM and CHEK2 may also be activated independently by a parallel pathway mediated by TP53BP1.

Molecular Weight

226666 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Mediator of DNA damage checkpoint protein 1

Subcellular Location

Nucleus

Protein Name

Mediator of DNA damage checkpoint protein 1

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