Anti-Phospho-CEP55 (S425) Antibody

Expressed in embryonic brain (PubMed:28264986) . Expressed in fetal brain ganglionic eminence, kidney tubules and multinucleate neurons in the temporal cortex (PubMed:28264986) . Expressed in adult brain, cerebellum, kidney tubules, intestine and muscles (at protein level) (PubMed:28295209, PubMed:28264986) . Widely expressed, mostly in proliferative tissues. Highly expressed in testis. Intermediate levels in adult and fetal thymus, as well as in various cancer cell lines. Low levels in different parts of the digestive tract, bone marrow, lymph nodes, placenta, fetal heart and fetal spleen. Hardly detected in brain.

Plays a role in mitotic exit and cytokinesis (PubMed:16198290, PubMed:17853893) . Recruits PDCD6IP and TSG101 to midbody during cytokinesis. Required for successful completion of cytokinesis (PubMed:17853893) . Not required for microtubule nucleation (PubMed:16198290) . Plays a role in the development of the brain and kidney (PubMed:28264986) .