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Anti-Phospho-ATR (S428) Antibody

Boster Bio Anti-Phospho-ATR (S428) Antibody catalog # A00262S428. Tested in ELISA, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Serine/threonine-protein kinase ATR;2.7.11.1; Ataxia telangiectasia and Rad3-related protein; FRAP-related protein 1; ATR; FRP1;

Gene Name

ATR

UniProt

Q13535

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human ATR around the phosphorylation site of Ser428. AA range:394-443

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with highest expression in testis. Isoform 2 is found in pancreas, placenta and liver but not in heart, testis and ovary.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication.

Molecular Weight

301367 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Serine/threonine-protein kinase ATR

Subcellular Location

Nucleus

Protein Name

Serine/threonine-protein kinase ATR

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