Anti-Phospho-MLK1/2 (T312/266) MAP3K9 Antibody

Boster Bio Anti-Phospho-MLK1/2 (T312/266) MAP3K9 Antibody catalog # A07599T312. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Mitogen-activated protein kinase kinase kinase 9;2.7.11.25; Mixed lineage kinase 1; MAP3K9; MLK1, PRKE1;

Gene Name

MAP3K9

UniProt

P80192

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human MLK1/2 around the phosphorylation site of Thr312/266. AA range:281-330

Clonality

Polyclonal

Tissue Specificity

Expressed in epithelial tumor cell lines of colonic, breast and esophageal origin.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Once activated, acts as an upstream activator of the MKK/JNK signal transduction cascade through the phosphorylation of MAP2K4/MKK4 and MAP2K7/MKK7 which in turn activate the JNKs. The MKK/JNK signaling pathway regulates stress response via activator protein-1 (JUN) and GATA4 transcription factors. Plays also a role in mitochondrial death signaling pathway, including the release cytochrome c, leading to apoptosis.