Anti-Phospho-MAD1 (S428) MAD1L1 Antibody

Boster Bio Anti-Phospho-MAD1 (S428) MAD1L1 Antibody catalog # A01137S428. Tested in ELISA, IHC applications. This antibody reacts with Human.

Product Specifications

Synonyms

Mitotic spindle assembly checkpoint protein MAD1; Mitotic arrest deficient 1-like protein 1; MAD1-like protein 1; Mitotic checkpoint MAD1 protein homolog; HsMAD1; hMAD1; Tax-binding protein 181; MAD1L1; MAD1, TXBP181;

Gene Name

MAD1L1

UniProt

Q9Y6D9

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human MAD1 around the phosphorylation site of Ser428. AA range:394-443

Clonality

Polyclonal

Tissue Specificity

Expressed weakly at G0/G1 and highly at late S and G2/M phase.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Component of the spindle-assembly checkpoint that prevents the onset of anaphase until all chromosomes are properly aligned at the metaphase plate. May recruit MAD2L1 to unattached kinetochores. Has a role in the correct positioning of the septum. Required for anchoring MAD2L1 to the nuclear periphery. Binds to the TERT promoter and represses telomerase expression, possibly by interfering with MYC binding.

Molecular Weight

83067 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01137S428

Product MSDS

https://www.bosterbio.com/msds?sku=A01137S428

Fragment

IgG

Other Gene Names

Mitotic spindle assembly checkpoint protein MAD1

Subcellular Location

Nucleus. Chromosome, centromere, kinetochore

Protein Name