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Anti-Phospho-RyR-2 (S2808) Antibody

Boster Bio Anti-Phospho-RyR-2 (S2808) Antibody catalog # A00155S2808. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Ryanodine receptor 2; RYR-2; RyR2; hRYR-2; Cardiac muscle ryanodine receptor; Cardiac muscle ryanodine receptor-calcium release channel; Type 2 ryanodine receptor; RYR2;

Gene Name

RYR2

UniProt

Q92736

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human RyR2 around the phosphorylation site of Ser2808. AA range:2774-2823

Clonality

Polyclonal

Tissue Specificity

Detected in heart muscle (at protein level) . Heart muscle, brain (cerebellum and hippocampus) and placenta.

Applications

IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Calcium channel that mediates the release of Ca (2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering cardiac muscle contraction. Aberrant channel activation can lead to cardiac arrhythmia. In cardiac myocytes, calcium release is triggered by increased Ca (2+) levels due to activation of the L-type calcium channel CACNA1C. The calcium channel activity is modulated by formation of heterotetramers with RYR3. Required for cellular calcium ion homeostasis. Required for embryonic heart development.

Molecular Weight

564567 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Ryanodine receptor 2

Subcellular Location

Sarcoplasmic reticulum membrane

Protein Name

Ryanodine receptor 2

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