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Anti-Phospho-NFATc1 (S294) Antibody

Boster Bio Anti-Phospho-NFATc1 (S294) Antibody catalog # A00340S294. Tested in ELISA, IHC applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Nuclear factor of activated T-cells, cytoplasmic 1; NF-ATc1; NFATc1; NFAT transcription complex cytosolic component; NF-ATc; NFATc; NFATC1; NFAT2, NFATC;

Gene Name

NFATC1

UniProt

O95644

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human NFAT2 around the phosphorylation site of Ser294. AA range:261-310

Clonality

Polyclonal

Tissue Specificity

Expressed in thymus, peripheral leukocytes as T-cells and spleen. Isoforms A are preferentially expressed in effector T-cells (thymus and peripheral leukocytes) whereas isoforms B and isoforms C are preferentially expressed in naive T- cells (spleen) . Isoforms B are expressed in naive T-cells after first antigen exposure and isoforms A are expressed in effector T- cells after second antigen exposure. Isoforms IA are widely expressed but not detected in liver nor pancreas, neural expression is strongest in corpus callosum. Isoforms IB are expressed mostly in muscle, cerebellum, placenta and thymus, neural expression in fetal and adult brain, strongest in corpus callosum.

Applications

ELISA, IHC-P

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 or IL-4 gene transcription. Also controls gene expression in embryonic cardiac cells. Could regulate not only the activation and proliferation but also the differentiation and programmed death of T-lymphocytes as well as lymphoid and non-lymphoid cells (PubMed:10358178) . Required for osteoclastogenesis and regulates many genes important for osteoclast differentiation and function (By similarity) .

Molecular Weight

101243 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00340S294

Product MSDS

https://www.bosterbio.com/msds?sku=A00340S294

Fragment

IgG

Other Gene Names

Nuclear factor of activated T-cells, cytoplasmic 1

Subcellular Location

Cytoplasm

Protein Name

Nuclear factor of activated T-cells, cytoplasmic 1

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