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Anti-Phospho-ErbB-3 (Y1222) Antibody

Boster Bio Anti-Phospho-ErbB-3 (Y1222) Antibody catalog # A00539Y1222. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Receptor tyrosine-protein kinase erbB-3;2.7.10.1; Proto-oncogene-like protein c-ErbB-3; Tyrosine kinase-type cell surface receptor HER3; ERBB3; HER3;

Gene Name

ERBB3

UniProt

P21860

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human HER3 around the phosphorylation site of Tyr1222. AA range:1191-1240

Clonality

Polyclonal

Tissue Specificity

Epithelial tissues and brain.

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Tyrosine-protein kinase that plays an essential role as cell surface receptor for neuregulins. Binds to neuregulin-1 (NRG1) and is activated by it; ligand-binding increases phosphorylation on tyrosine residues and promotes its association with the p85 subunit of phosphatidylinositol 3-kinase (PubMed:20682778) . May also be activated by CSPG5 (PubMed:15358134) .

Molecular Weight

148098 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Receptor tyrosine-protein kinase erbB-3

Subcellular Location

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Protein Name

Receptor tyrosine-protein kinase erbB-3

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