Anti-Phospho-BLM (T99) Antibody

Boster Bio Anti-Phospho-BLM (T99) Antibody catalog # A00724T99. Tested in ELISA, IF, IHC, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Bloom syndrome protein;3.6.4.12

Gene Name

BLM

UniProt

P54132

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human Bloom Syndrome around the phosphorylation site of Thr99. AA range:65-114

Clonality

Polyclonal

Applications

WB, IHC, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

ATP-dependent DNA helicase that unwinds single- and double-stranded DNA in a 3'-5' direction (PubMed:9388193, PubMed:24816114, PubMed:25901030) . Participates in DNA replication and repair (PubMed:12019152, PubMed:21325134, PubMed:23509288) . Involved in 5'-end resection of DNA during double-strand break (DSB) repair: unwinds DNA and recruits DNA2 which mediates the cleavage of 5'-ssDNA (PubMed:21325134) . Negatively regulates sister chromatid exchange (SCE) (PubMed:25901030) . Stimulates DNA 4-way junction branch migration and DNA Holliday junction dissolution (PubMed:25901030) . Binds single-stranded DNA (ssDNA), forked duplex DNA and DNA Holliday junction (PubMed:20639533, PubMed:24257077, PubMed:25901030) .