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Anti-Phospho-Smad2 (S465) Antibody

Boster Bio Anti-Phospho-Smad2 (S465) Antibody catalog # A00090S465. Tested in ELISA, IHC-P, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2, MADR2;

Gene Name

SMAD2

UniProt

Q15796

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Smad2 (phospho Ser465)

Clonality

Polyclonal

Tissue Specificity

Expressed at high levels in skeletal muscle, endothelial cells, heart and placenta.

Applications

ELISA, IHC-P, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Molecular Weight

52306 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00090S465

Product MSDS

https://www.bosterbio.com/msds?sku=A00090S465

Fragment

IgG

Other Gene Names

Mothers against decapentaplegic homolog 2

Subcellular Location

Cytoplasm

Protein Name

Mothers against decapentaplegic homolog 2

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