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Anti-Phospho-SREBP-1 (S439) SREBF1 Antibody

Boster Bio Anti-Phospho-SREBP-1 (S439) SREBF1 Antibody catalog # A00282S439-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Rat.

Product Specifications

Synonyms

Sterol regulatory element-binding protein 1; SREBP-1; Class D basic helix-loop-helix protein 1; bHLHd1; Sterol regulatory element-binding transcription factor 1; Processed sterol regulatory element-binding protein 1; SREBF1; BHLHD1, SREBP1;

Gene Name

SREBF1

UniProt

P36956

Host

Rabbit

Reactivity

Human, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human SREBP-1 around the phosphorylation site of Ser439. AA range:405-454

Clonality

Polyclonal

Tissue Specificity

Expressed in a wide variety of tissues, most abundant in liver and adrenal gland. In fetal tissues lung and liver shows highest expression. Isoform SREBP-1C predominates in liver, adrenal gland and ovary, whereas isoform SREBP-1A predominates in hepatoma cell lines. Isoform SREBP-1A and isoform SREBP-1C are found in kidney, brain, white fat, and muscle.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Transcriptional activator required for lipid homeostasis. Regulates transcription of the LDL receptor gene as well as the fatty acid and to a lesser degree the cholesterol synthesis pathway (By similarity) . Binds to the sterol regulatory element 1 (SRE-1) (5'-ATCACCCCAC-3') . Has dual sequence specificity binding to both an E-box motif (5'-ATCACGTGA-3') and to SRE-1 (5'-ATCACCCCAC-3') .

Molecular Weight

121675 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00282S439-1

Product MSDS

https://www.bosterbio.com/msds?sku=A00282S439-1

Fragment

IgG

Other Gene Names

Sterol regulatory element-binding protein 1

Subcellular Location

Endoplasmic reticulum membrane

Protein Name

Sterol regulatory element-binding protein 1

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