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Anti-Phospho-Cyclin C (S275) CCNC Antibody

Boster Bio Anti-Phospho-Cyclin C (S275) CCNC Antibody catalog # A05832S275. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Cyclin-C; SRB11 homolog; hSRB11; CCNC;

Gene Name

CCNC

UniProt

P24863

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Cyclin C around the phosphorylation site of Ser275. AA range:234-283

Clonality

Polyclonal

Tissue Specificity

Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.

Molecular Weight

33243 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A05832S275

Product MSDS

https://www.bosterbio.com/msds?sku=A05832S275

Fragment

IgG

Other Gene Names

Cyclin-C

Subcellular Location

Nucleus .

Protein Name

Cyclin-C

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