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Anti-Phospho-WASP (Y290) Antibody

Boster Bio Anti-Phospho-WASP (Y290) Antibody catalog # A10788Y290. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Wiskott-Aldrich syndrome protein; WASp; WAS; IMD2;

Gene Name

WAS

UniProt

P42768

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human WASP around the phosphorylation site of Tyr290. AA range:256-305

Clonality

Polyclonal

Tissue Specificity

Expressed predominantly in the thymus. Also found, to a much lesser extent, in the spleen.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Effector protein for Rho-type GTPases that regulates actin filament reorganization via its interaction with the Arp2/3 complex (PubMed:12235133, PubMed:12769847, PubMed:16275905) . Important for efficient actin polymerization (PubMed:8625410, PubMed:12235133, PubMed:16275905) . Possible regulator of lymphocyte and platelet function (PubMed:9405671) . Mediates actin filament reorganization and the formation of actin pedestals upon infection by pathogenic bacteria (PubMed:18650809) . In addition to its role in the cytoplasmic cytoskeleton, also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:20574068) . Promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947) .

Molecular Weight

52913 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Wiskott-Aldrich syndrome protein

Subcellular Location

Cytoplasm, cytoskeleton

Protein Name

Wiskott-Aldrich syndrome protein

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