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Anti-Phospho-Tuberin (S939) TSC2 Antibody

Boster Bio Anti-Phospho-Tuberin (S939) TSC2 Antibody catalog # A00229S939-1. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Tuberin; Tuberous sclerosis 2 protein; TSC2; TSC4;

Gene Name

TSC2

UniProt

P49815

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Tuberin/TSC2 around the phosphorylation site of Ser939. AA range:905-954

Clonality

Polyclonal

Tissue Specificity

Liver, brain, heart, lymphocytes, fibroblasts, biliary epithelium, pancreas, skeletal muscle, kidney, lung and placenta.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

In complex with TSC1, this tumor suppressor inhibits the nutrient-mediated or growth factor-stimulated phosphorylation of S6K1 and EIF4EBP1 by negatively regulating mTORC1 signaling (PubMed:12271141, PubMed:28215400) . Acts as a GTPase-activating protein (GAP) for the small GTPase RHEB, a direct activator of the protein kinase activity of mTORC1 (PubMed:15340059) . May also play a role in microtubule-mediated protein transport (By similarity) . Also stimulates the intrinsic GTPase activity of the Ras-related proteins RAP1A and RAB5 (By similarity) .

Molecular Weight

200608 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Tuberin

Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein. At steady state found in association with membranes.

Protein Name

Tuberin

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