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Anti-Phospho-Crk II (Y221) Antibody

Boster Bio Anti-Phospho-Crk II (Y221) Antibody catalog # A02533Y221-1. Tested in ELISA, IF, WB applications. This antibody reacts with Human, Monkey, Mouse, Rat.

Product Specifications

Synonyms

Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK;

Gene Name

CRK

UniProt

P46108

Host

Rabbit

Reactivity

Human, Mouse, Rat, Monkey

Immunogen

The antiserum was produced against synthesized peptide derived from human CrkII around the phosphorylation site of Tyr221. AA range:187-236

Clonality

Polyclonal

Applications

WB, IF, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Isoform Crk-II: Regulates cell adhesion, spreading and migration. Mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling.

Molecular Weight

33831 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Adapter molecule crk

Subcellular Location

Cytoplasm . Cell membrane . Translocated to the plasma membrane upon cell adhesion. .

Protein Name

Adapter molecule crk

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