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Anti-Phospho-PAK5/6 (S602/S560) Antibody

Boster Bio Anti-Phospho-PAK5/6 (S602/S560) Antibody catalog # A31791S602S560. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Serine/threonine-protein kinase PAK 5 ;2.7.11.1; p21-activated kinase 5; PAK-5; p21-activated kinase 7; PAK-7; PAK5

Gene Name

PAK5

UniProt

Q9P286

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human PAK5/6 around the phosphorylation site of Ser602/Ser560. AA range:566-615

Clonality

Polyclonal

Tissue Specificity

Predominantly expressed in brain.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, proliferation or cell survival. Activation by various effectors including growth factor receptors or active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates the proto-oncogene RAF1 and stimulates its kinase activity. Promotes cell survival by phosphorylating the BCL2 antagonist of cell death BAD. Phosphorylates CTNND1, probably to regulate cytoskeletal organization and cell morphology. Keeps microtubules stable through MARK2 inhibition and destabilizes the F-actin network leading to the disappearance of stress fibers and focal adhesions.

Molecular Weight

80745 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A31791S602S560

Product MSDS

https://www.bosterbio.com/msds?sku=A31791S602S560

Fragment

IgG

Other Gene Names

Serine/threonine-protein kinase PAK 5

Subcellular Location

Mitochondrion. Cytoplasm. Nucleus. Shuttles between the nucleus and the mitochondria, and mitochondrial localization is essential for the role in cell survival.

Protein Name

Serine/threonine-protein kinase PAK 5

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