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Anti-Phospho-GRK 2 (S685) Antibody

Boster Bio Anti-Phospho-GRK 2 (S685) Antibody catalog # A32388S685. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Beta-adrenergic receptor kinase 1; Beta-ARK-1;2.7.11.15

Gene Name

GRK2

UniProt

P25098

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human GRK2 around the phosphorylation site of Ser685. AA range:640-689

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood leukocytes.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378) . Positively regulates ciliary smoothened (SMO) - dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity) .

Molecular Weight

79574 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Beta-adrenergic receptor kinase 1

Subcellular Location

Cytoplasm

Protein Name

Beta-adrenergic receptor kinase 1

Frequently Asked Questions

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