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Anti-Phospho-CD28 (Y218) Antibody

Boster Bio Anti-Phospho-CD28 (Y218) Antibody catalog # A00065Y218. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

T-cell-specific surface glycoprotein CD28; TP44; CD28; CD28;

Gene Name

CD28

UniProt

P10747

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human CD28 around the phosphorylation site of Tyr218. AA range:171-220

Clonality

Polyclonal

Tissue Specificity

Expressed in T-cells and plasma cells, but not in less mature B-cells.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933) . Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037) .

Molecular Weight

25066 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

T-cell-specific surface glycoprotein CD28

Subcellular Location

Membrane; Single-pass type I membrane protein.

Protein Name

T-cell-specific surface glycoprotein CD28

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