Anti-Phospho-Caspase-9 (S196) CASP9 Antibody

Boster Bio Anti-Phospho-Caspase-9 (S196) CASP9 Antibody catalog # A00080S196. Tested in ELISA, IHC-P, WB applications. This antibody reacts with Human.

Product Specifications

Synonyms

Caspase-9; CASP-9;3.4.22.62

Gene Name

CASP9

UniProt

P55211

Host

Rabbit

Reactivity

Human

Immunogen

The antiserum was produced against synthesized peptide derived from human Caspase 9 around the phosphorylation site of Ser196. AA range:162-211

Clonality

Polyclonal

Tissue Specificity

Ubiquitous, with highest expression in the heart, moderate expression in liver, skeletal muscle, and pancreas. Low levels in all other tissues. Within the heart, specifically expressed in myocytes.

Applications

ELISA, IHC-P, WB

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf- 1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly (ADP- ribose) polymerase (PARP) .