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Anti-Phospho-HDAC5/9 (S259/220) Antibody

Boster Bio Anti-Phospho-HDAC5/9 (S259/220) Antibody catalog # A01230S259. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

Histone deacetylase 5; HD5;3.5.1.98; Antigen NY-CO-9; HDAC5; KIAA0600;

Gene Name

HDAC5

UniProt

Q9UQL6

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

The antiserum was produced against synthesized peptide derived from human HDAC5 around the phosphorylation site of Ser259. AA range:225-274

Clonality

Polyclonal

Tissue Specificity

Ubiquitous.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) . Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Involved in muscle maturation by repressing transcription of myocyte enhancer MEF2C. During muscle differentiation, it shuttles into the cytoplasm, allowing the expression of myocyte enhancer factors. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.

Molecular Weight

121978 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A01230S259

Product MSDS

https://www.bosterbio.com/msds?sku=A01230S259

Fragment

IgG

Other Gene Names

Histone deacetylase 5

Subcellular Location

Nucleus. Cytoplasm. Shuttles between the nucleus and the cytoplasm. In muscle cells, it shuttles into the cytoplasm during myocyte differentiation. The export to cytoplasm depends on the interaction with a 14-3-3 chaperone protein and is due to its phosphorylation at Ser-259 and Ser-498 by AMPK, CaMK1 and SIK1.

Protein Name

Histone deacetylase 5

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