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Anti-Phospho-Shb (Y246) Antibody

Boster Bio Anti-Phospho-Shb (Y246) Antibody catalog # A02109Y246-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

SH2 domain-containing adapter protein B; SHB;

Gene Name

SHB

UniProt

Q15464

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized phospho-peptide around the phosphorylation site of human Shb (phospho Tyr246)

Clonality

Polyclonal

Tissue Specificity

Widely expressed.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Adapter protein which regulates several signal transduction cascades by linking activated receptors to downstream signaling components. May play a role in angiogenesis by regulating FGFR1, VEGFR2 and PDGFR signaling. May also play a role in T-cell antigen receptor/TCR signaling, interleukin-2 signaling, apoptosis and neuronal cells differentiation by mediating basic- FGF and NGF-induced signaling cascades. May also regulate IRS1 and IRS2 signaling in insulin-producing cells.

Molecular Weight

55042 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

SH2 domain-containing adapter protein B

Subcellular Location

Cytoplasm. Cell membrane; Peripheral membrane protein; Cytoplasmic side. Associates with membrane lipid rafts upon TCR stimulation.

Protein Name

SH2 domain-containing adapter protein B

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