Anti-Phospho-Caveolin-1 (Y14) CAV1 Antibody

Boster Bio Anti-Phospho-Caveolin-1 (Y14) CAV1 Antibody catalog # A00179Y14. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Caveolin-1; CAV1; CAV;

Gene Name

CAV1

UniProt

Q03135

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Caveolin-1 around the phosphorylation site of Tyr14. AA range:5-54

Clonality

Polyclonal

Tissue Specificity

Skeletal muscle, liver, stomach, lung, kidney and heart (at protein level) . Expressed in the brain.

Applications

WB, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity) . Involved in the costimulatory signal essential for T-cell receptor (TCR) - mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3- dependent manner. Recruits CTNNB1 to caveolar membranes and may regulate CTNNB1-mediated signaling through the Wnt pathway. Negatively regulates TGFB1-mediated activation of SMAD2/3 by mediating the internalization of TGFBR1 from membrane rafts leading to its subsequent degradation (PubMed:25893292) . Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (PubMed:19262564) .