Anti-Cleaved-Factor B Bb (K260) CFB Antibody

Complement factor B;3.4.21.47; C3/C5 convertase; Glycine-rich beta glycoprotein; GBG; PBF2; Properdin factor B; Complement factor B Ba fragment; Complement factor B Bb fragment; CFB; BF, BFD;

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B- lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.