Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

Anti-Cleaved-Notch 2 (D1733) Antibody

Boster Bio Anti-Cleaved-Notch 2 (D1733) Antibody catalog # A00518-3. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; N2ECD

Gene Name

NOTCH2

UniProt

Q04721

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Notch 2. AA range:1684-1733

Clonality

Polyclonal

Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989) . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) . Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL- induced osteoclast differentiation (PubMed:29149593) . Positively regulates self-renewal of liver cancer cells (PubMed:25985737) .

Molecular Weight

265405 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Product Datasheet

https://www.bosterbio.com/datasheet?sku=A00518-3

Product MSDS

https://www.bosterbio.com/msds?sku=A00518-3

Fragment

IgG

Other Gene Names

Neurogenic locus notch homolog protein 2

Subcellular Location

Notch 2 extracellular truncation: Cell membrane

Protein Name

Neurogenic locus notch homolog protein 2

Curated Selection

Explore Other Products

Discover premium biology products from our extensive collection of 20M+ items

PI 3 Kinase reguLatory subunit 4 (PIK3R4) (NM_014602) Human Recombinant Protein
TP310308M 100 µg

PI 3 Kinase reguLatory subunit 4 (PIK3R4) (NM_014602) Human Recombinant Protein

Ask
View Details
Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit
MBS749829-01 48 Well

Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit

Ask
View Details
Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit
MBS749829-02 96 Well

Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit

Ask
View Details
Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit
MBS749829-03 5x 96 Well

Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit

Ask
View Details
Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit
MBS749829-04 10x 96 Well

Bovine Phosphorylated c-Jun N-terminal kinases/stress-activated protein kinase ELISA Kit

Ask
View Details
Recombinant Human Kynureninase (C-His)
BP2447-50ug 50 µg

Recombinant Human Kynureninase (C-His)

Ask
View Details