What is the catalog number for Anti-Cleaved-Notch 2 (D1733) Antibody?

The catalog number for Anti-Cleaved-Notch 2 (D1733) Antibody is A00518-3.

What sizes are available for Anti-Cleaved-Notch 2 (D1733) Antibody?

Anti-Cleaved-Notch 2 (D1733) Antibody is available in the following size(s): 100 µL.

Is Anti-Cleaved-Notch 2 (D1733) Antibody in stock?

Anti-Cleaved-Notch 2 (D1733) Antibody is currently made to order / not held in immediate stock. Contact us for lead time.

Where can I find the safety data sheet (SDS/MSDS) for Anti-Cleaved-Notch 2 (D1733) Antibody?

The safety data sheet for Anti-Cleaved-Notch 2 (D1733) Antibody is available here: https://www.bosterbio.com/msds?sku=A00518-3.

Anti-Cleaved-Notch 2 (D1733) Antibody

Boster Bio Anti-Cleaved-Notch 2 (D1733) Antibody catalog # A00518-3. Tested in ELISA, IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Neurogenic locus notch homolog protein 2; Notch 2; hN2; Notch 2 extracellular truncation; N2ECD

Gene Name

NOTCH2

UniProt

Q04721

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

The antiserum was produced against synthesized peptide derived from human Notch 2. AA range:1684-1733

Clonality

Polyclonal

Tissue Specificity

Expressed in the brain, heart, kidney, lung, skeletal muscle and liver. Ubiquitously expressed in the embryo.

Applications

WB, IHC, ELISA

Purification

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Form

Liquid

Function

Functions as a receptor for membrane-bound ligands Jagged-1 (JAG1), Jagged-2 (JAG2) and Delta-1 (DLL1) to regulate cell-fate determination. Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus (PubMed:21378985, PubMed:21378989) . Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) . Involved in bone remodeling and homeostasis. In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL- induced osteoclast differentiation (PubMed:29149593) . Positively regulates self-renewal of liver cancer cells (PubMed:25985737) .