Anti-Doublecortin (Phospho-Ser378) DCX Antibody

Boster Bio Anti-Doublecortin (Phospho-Ser378) DCX Antibody catalog # A01053S378. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Neuronal migration protein doublecortin; Doublin; Lissencephalin-X; Lis-X; DCX; DBCN, LISX;

Gene Name

DCX

UniProt

O43602

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human Doublecortin (Phospho-Ser378)

Clonality

Polyclonal

Tissue Specificity

Highly expressed in neuronal cells of fetal brain (in the majority of cells of the cortical plate, intermediate zone and ventricular zone), but not expressed in other fetal tissues. In the adult, highly expressed in the brain frontal lobe, but very low expression in other regions of brain, and not detected in heart, placenta, lung, liver, skeletal muscles, kidney and pancreas.

Applications

IHC, WB

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, WB 1:500-2000

Form

Liquid

Function

Microtubule-associated protein required for initial steps of neuronal dispersion and cortex lamination during cerebral cortex development. May act by competing with the putative neuronal protein kinase DCLK1 in binding to a target protein. May in that way participate in a signaling pathway that is crucial for neuronal interaction before and during migration, possibly as part of a calcium ion-dependent signal transduction pathway. May be part with PAFAH1B1/LIS-1 of overlapping, but distinct, signaling pathways that promote neuronal migration.