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Anti-GRK2 (Phospho-Tyr86) Antibody

Boster Bio Anti-GRK2 (Phospho-Tyr86) Antibody catalog # A32388Y86. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Beta-adrenergic receptor kinase 1; Beta-ARK-1;2.7.11.15

Gene Name

GRK2

UniProt

P25098

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from human GRK2 (Phospho-Tyr86)

Clonality

Polyclonal

Tissue Specificity

Expressed in peripheral blood leukocytes.

Applications

IHC, WB

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, WB 1:500-2000

Form

Liquid

Function

Specifically phosphorylates the agonist-occupied form of the beta-adrenergic and closely related receptors, probably inducing a desensitization of them. Key regulator of LPAR1 signaling. Competes with RALA for binding to LPAR1 thus affecting the signaling properties of the receptor. Desensitizes LPAR1 and LPAR2 in a phosphorylation-independent manner (PubMed:19306925, PubMed:19715378) . Positively regulates ciliary smoothened (SMO) - dependent Hedgehog (Hh) signaling pathway by faciltating the trafficking of SMO into the cilium and the stimulation of SMO activity (By similarity) .

Molecular Weight

79574 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

Beta-adrenergic receptor kinase 1

Subcellular Location

Cytoplasm

Protein Name

Beta-adrenergic receptor kinase 1

Frequently Asked Questions

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