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Anti-RNA demethylase ALKBH5 ALKBH5 Antibody

Boster Bio Anti-RNA demethylase ALKBH5 ALKBH5 Antibody catalog # A03360-2. Tested in IHC, WB applications. This antibody reacts with Human, Mouse.

Product Specifications

Synonyms

RNA demethylase ALKBH5

Gene Name

ALKBH5

UniProt

Q6P6C2

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Synthesized peptide derived from human ALKBH5

Clonality

Polyclonal

Tissue Specificity

Widely expressed, with highest expression in lung, followed by testis, pancreas, spleen and ovary.

Applications

IHC, WB

Purification

The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.

Concentration

1 mg/ml

Dilution

IHC-p 1:50-200, WB 1:500-2000

Form

Liquid

Function

Dioxygenase that demethylates RNA by oxidative demethylation: specifically demethylates N (6) -methyladenosine (m6A) RNA, the most prevalent internal modification of messenger RNA (mRNA) in higher eukaryotes (PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Can also demethylate N (6) - methyladenosine in single-stranded DNA (in vitro) (PubMed:24616105) . Requires molecular oxygen, alpha-ketoglutarate and iron (PubMed:21264265, PubMed:23177736, PubMed:24778178, PubMed:24616105, PubMed:24489119) . Demethylation of m6A mRNA affects mRNA processing and export (PubMed:23177736) . Required for spermatogenesis (By similarity) .

Molecular Weight

44256 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Other Gene Names

RNA demethylase ALKBH5

Subcellular Location

Nucleus speckle

Protein Name

RNA demethylase ALKBH5

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