Anti-Transcription factor NF-E4 NFE4 Antibody
Boster Bio Anti-Transcription factor NF-E4 NFE4 Antibody catalog # A14260-1. Tested in IHC, WB applications. This antibody reacts with Human.
Product Specifications
Synonyms
Transcription factor NF-E4; NFE4;
Gene Name
NFE4
UniProt
Q86UQ8
Host
Rabbit
Reactivity
Human
Immunogen
Synthesized peptide derived from human NF-E4
Clonality
Polyclonal
Tissue Specificity
Specifically expressed in fetal liver, cord blood and bone marrow. Also expressed in the K562 and HEL cell lines, which constitutively express the fetal globin genes.
Applications
IHC, WB
Purification
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen.
Concentration
1 mg/ml
Dilution
IHC-p 1:50-200, WB 1:500-2000
Form
Liquid
Function
Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR) . The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma- globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter.
Molecular Weight
19019 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Other Gene Names
Transcription factor NF-E4
Subcellular Location
Nucleus .
Protein Name
Transcription factor NF-E4
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