Anti-Derlin-2 DERL2 Antibody
Boster Bio Anti-Derlin-2 DERL2 Antibody catalog # A08998. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse.
Product Specifications
Synonyms
Derlin-2
Gene Name
DERL2
UniProt
Q9GZP9
Host
Rabbit
Reactivity
Human, Mouse
Immunogen
Synthesized peptide derived from part region of human protein
Clonality
Polyclonal
Tissue Specificity
Ubiquitous. Overexpressed in various hepatocarcinomas.
Applications
WB, ELISA
Purification
DERL2 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
1 mg/ml
Dilution
WB 1:500-2000 ELISA 1:5000-20000
Form
Liquid
Function
Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and misfolded glycoproteins (PubMed:16186509, PubMed:16449189) . May also be involved in endoplasmic reticulum stress-induced pre-emptive quality control, a mechanism that selectively attenuates the translocation of newly synthesized proteins into the endoplasmic reticulum and reroutes them to the cytosol for proteasomal degradation (PubMed:26565908) .
Molecular Weight
27567 MW
Shipping Conditions
Available
Storage Conditions
Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.
Fragment
IgG
Other Gene Names
Derlin-2
Subcellular Location
Endoplasmic reticulum membrane
Protein Name
Derlin-2
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