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Anti-ZEB1 Antibody

Boster Bio Anti-ZEB1 Antibody catalog # A00548-1. Tested in ELISA, WB applications. This antibody reacts with Human, Mouse, Rat.

Product Specifications

Synonyms

Zinc finger E-box-binding homeobox 1; NIL-2-A zinc finger protein; Negative regulator of IL2; Transcription factor 8; TCF-8; ZEB1; AREB6, TCF8;

Gene Name

ZEB1

UniProt

P37275

Host

Rabbit

Reactivity

Human, Mouse, Rat

Immunogen

Synthesized peptide derived from part region of human protein

Clonality

Polyclonal

Tissue Specificity

Colocalizes with SMARCA4/BRG1 in E-cadherin- negative cells from established lines, and stroma of normal colon as well as in de-differentiated epithelial cells at the invasion front of colorectal carcinomas (at protein level) . Expressed in heart and skeletal muscle, but not in liver, spleen, or pancreas.

Applications

WB, ELISA

Purification

ZEB1 antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Concentration

1 mg/ml

Dilution

WB 1:500-2000 ELISA 1:5000-20000

Form

Liquid

Function

Acts as a transcriptional repressor. Inhibits interleukin-2 (IL-2) gene expression. Enhances or represses the promoter activity of the ATP1A1 gene depending on the quantity of cDNA and on the cell type. Represses E-cadherin promoter and induces an epithelial-mesenchymal transition (EMT) by recruiting SMARCA4/BRG1. Represses BCL6 transcription in the presence of the corepressor CTBP1. Positively regulates neuronal differentiation. Represses RCOR1 transcription activation during neurogenesis. Represses transcription by binding to the E box (5'-CANNTG-3') . Promotes tumorigenicity by repressing stemness-inhibiting microRNAs.

Molecular Weight

124074 MW

Shipping Conditions

Available

Storage Conditions

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

Fragment

IgG

Other Gene Names

Zinc finger E-box-binding homeobox 1

Subcellular Location

Nucleus

Protein Name

Zinc finger E-box-binding homeobox 1

Frequently Asked Questions

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