Anti-GP183 GPR183 Antibody

Expressed abundantly in lymphoid tissues such as spleen and lymph node, and in B- and T-lymphocytes (PubMed:16540462, PubMed:8383238) . Also highly expressed in lung, heart and gastrointestinal tract, and weakly expressed in the urogenital system and brain (PubMed:16540462, PubMed:8383238) . Expressed in astrocytes (PubMed:25297897) .

G-protein coupled receptor expressed in lymphocytes that acts as a chemotactic receptor for B-cells, T-cells, splenic dendritic cells, monocytes/macrophages and astrocytes (By similarity) . Receptor for oxysterol 7-alpha,25- dihydroxycholesterol (7-alpha,25-OHC) and other related oxysterols (PubMed:21796212, PubMed:22875855, PubMed:22930711) . Mediates cell positioning and movement of a number of cells by binding the 7- alpha,25-OHC ligand that forms a chemotactic gradient (By similarity) . Binding of 7-alpha,25-OHC mediates the correct localization of B-cells during humoral immune responses (By similarity) . Guides B-cell movement along the B-cell zone-T-cell zone boundary and later to interfollicular and outer follicular regions (By similarity) . Its specific expression during B-cell maturation helps position B-cells appropriately for mounting T- dependent antibody responses (By similarity) . Collaborates with CXCR5 to mediate B-cell migration; probably by forming a heterodimer with CXCR5 that affects the interaction between of CXCL13 and CXCR5 (PubMed:22913878) . Also acts as a chemotactic receptor for some T-cells upon binding to 7-alpha,25-OHC ligand (By similarity) . Promotes follicular helper T (Tfh) cells differentiation by positioning activated T-cells at the follicle- T-zone interface, promoting contact of newly activated CD4 T-cells with activated dendritic cells and exposing them to Tfh-cell- promoting inducible costimulator (ICOS) ligand (By similarity) . Expression in splenic dendritic cells is required for their homeostasis, localization and ability to induce B- and T-cell responses: GPR183 acts as a chemotactic receptor in dendritic cells that mediates the accumulation of CD4 (+) dendritic cells in bridging channels (By similarity) . Regulates migration of astrocytes and is involved in communication between astrocytes and macrophages (PubMed:25297897) . Promotes osteoclast precursor migration to bone surfaces (By similarity) . Signals constitutively through G (i) -alpha, but not G (s) -alpha or G (q) -alpha (PubMed:21673108, PubMed:25297897) . Signals constitutively also via MAPK1/3 (ERK1/2) (By similarity) .