Anti-TRI56 TRIM56 Antibody

E3 ubiquitin-protein ligase TRIM56;2.3.2.27; RING finger protein 109; RING-type E3 ubiquitin transferase TRIM56 ; Tripartite motif-containing protein 56; TRIM56; RNF109;

E3 ubiquitin-protein ligase that plays a key role in innate antiviral immunity (PubMed:21289118) . In response to pathogen- and host-derived double-stranded DNA (dsDNA), targets TMEM173/STING to 'Lys-63'-linked ubiquitination, thereby promoting its homodimerization, a step required for the production of type I interferon IFN-beta (By similarity) . Independently of its E3 ubiquitin ligase activity, positive regulator of TLR3 signaling. Potentiates extracellular double stranded RNA (dsRNA) -induced expression of IFNB1 and interferon-stimulated genes ISG15, IFIT1/ISG56, CXCL10, OASL and CCL5/RANTES. Promotes establishment of an antiviral state by TLR3 ligand and TLR3-mediated chemokine induction following infection by hepatitis C virus (PubMed:22948160) .