Anti-SLUR1 SLURP1 Antibody

Granulocytes. Expressed in skin. Predominantly expressed in the granular layer of skin, notably the acrosyringium. Identified in several biological fluids such as sweat, saliva, tears, plasma and urine.

Has an antitumor activity (PubMed:8742060) . Was found to be a marker of late differentiation of the skin. Implicated in maintaining the physiological and structural integrity of the keratinocyte layers of the skin (PubMed:14721776, PubMed:17008884) . In vitro down-regulates keratinocyte proliferation; the function may involve the proposed role as modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-7-dependent nAChR currents in an allosteric manner (PubMed:14506129, PubMed:26905431) . In T cells may be involved in regulation of intracellular Ca (2+) signaling (PubMed:17286989) . Seems to have a immunomodulatory function in the cornea (By similarity) . The function may implicate a possible role as a scavenger receptor for PLAU thereby blocking PLAU- dependent functions of PLAUR such as in cell migration and proliferation (PubMed:25168896) .